Behavioral and electrophysiological correlates of cognitive control in ex-obese adults

- Cognitive control was assessed in ex-obese individuals after bariatric surgery.
- Two Stroop tasks, a Switching task and a Go/NoGo task were administered.
- Ex-obese individuals showed higher verbal Stroop effect and switch cost.
- An attenuated switch-positivity reflected altered proactive control processes.
- More pronounced NoGo-N2 revealed higher involvement of conflict monitoring.

Impaired cognitive control functions have been documented in obesity. It remains unclear whether these functions normalize after weight reduction. We compared ex-obese individuals, who successfully underwent substantial weight loss after bariatric surgery, to normal-weight participants on measures of resistance to interference, cognitive flexibility and response inhibition, obtained from the completion of two Stroop tasks, a Switching task and a Go/NoGo task, respectively. To elucidate the underlying brain mechanisms, event-related potentials (ERPs) in the latter two tasks were examined. As compared to controls, patients were more susceptible to the predominant but task-irrelevant stimulus dimension (i.e., they showed a larger verbal Stroop effect), and were slower in responding on trials requiring a task-set change rather than a task-set repetition (i.e., they showed a larger switch cost). The ERP correlates revealed altered anticipatory control mechanisms (switch positivity) and an exaggerated conflict monitoring response (N2). The results suggest that cognitive control is critical even in ex-obese individuals and should be monitored to promote weight loss maintenance.