کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5041192 | 1473960 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Early presence of depressive symptoms in PD is a marker of faster neurodegeneration.
- Depressive symptoms in PD correlate with a higher neurodegeneration rate over time.
- These preliminary results indicate that even mild depressive symptoms should be treated early in PD.
IntroductionDepressive symptoms are very common in patients with Parkinson's disease (PD) and have a significant impact on the quality of life.MethodsThe present study analyzed the correlations between over-time changes in depressive symptoms and gray matter parameters of cortical thickness and subcortical volumes in non-demented PD patients.ResultsA significant correlation was observed, between increased scores for depression over time and lower cortical thickness over time in the right temporo-parietal junction, right occipital medial region, right dorsolateral prefrontal cortex, right posterior cingulate region, left middle temporal as well as left supplementary motor area. Furthermore, the presence of depressive symptoms at baseline predicted increased cortical thinning over time in the left middle temporal, left anterior cingulate, right posterior cingulate and right parahippocampal cortices. Finally, a statistically significant negative correlation has been revealed between the thalamus' volume changes over time and the change in depressive symptoms scores. All other analyzed subcortical structures didn't reveal any significant correlations.ConclusionThese results suggest that depressive symptoms in PD patients are associated with gray matter cortical thinning and thalamus volume shrinkage over time and higher scores of depressive symptoms at baseline correlate with a higher rate of cortical thinning longitudinally. The present study highlights the importance of addressing depressive symptoms in PD patients early in the disease.
Journal: Brain and Cognition - Volume 111, February 2017, Pages 127-133