BDNF controls object recognition memory reconsolidation

- Blocking BDNF signaling after retrieval impairs object memory reconsolidation.
- Retrieval increases BDNF and decreases pro-BDNF levels in the hippocampus.
- Exogenous BDNF reverses the amnesic effect of the post-retrieval administration of mRNA and protein synthesis inhibitors.

Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1 impairs updating of the reactivated recognition memory trace.