کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5043260 | 1475138 | 2016 | 6 صفحه PDF | دانلود رایگان |
- Activation of HO neurons increases the expression of the activity marker c-Fos.
- HO activation improves spatial short-term memory for novel locations.
- Similar increases in HO activity had no effect on object recognition memory.
The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.
Journal: Neurobiology of Learning and Memory - Volume 136, December 2016, Pages 183-188