کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5043272 1475140 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of 7-nitroindazole, a selective neural nitric oxide synthase inhibitor, on context-shock associative learning in a two-process contextual fear conditioning paradigm
ترجمه فارسی عنوان
اثرات 7-نیترویندازول، یک مهارکننده سنتاز نیکروکسیدکربنیک انتخابی، در یادگیری وابسته به متابولیسم متناوب در یک پارادایم متداول ترسیم دو مرحله ای متضاد
کلمات کلیدی
اکسید نیتریک، 7-نیترین دیزل، تهدید متضاد دو مرحله ای، نیاسین اکسید سنتاز،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- 7-Nitroindazole inhibited contextual fear conditioning.
- Nitric oxide is specifically involved in the acquisition but not consolidation of contextual fear memory.
- Nitric oxide is not involved in the formation of conjunctive contextual representations.

Nitric oxide (NO) is an important retrograde neuronal intracellular messenger which plays an important role in synaptic plasticity and is involved in learning and memory. However, evidence that NO is particularly important for the acquisition of contextual fear conditioning is mixed. Also, little is known about at which stages of the contextual fear conditioning does NO make its contribution. In the present study, we used 7-nitroindazole to temporarily inhibit neural nitric oxide synthase at either the pre-exposure stage or conditioning stage in a two-process paradigm and examined the potential contribution that NO makes to the contextually conditioned fear. Results showed that the expression of contextual fear memory was significantly impaired in rats treated with 7-nitroindazole (30 mg/kg, i.p.) prior to the pairing of context-shock (p = 0.034, n = 8), but not after the conditioning phase (p = 0.846, n = 8). In addition, the expression of contextual fear memory and reconsolidation was not significantly impaired by 7-nitroindazole administered prior to the context pre-exposure stage or prior to another context-shock learning. These findings suggest that NO is specifically involved in the acquisition but not the consolidation, retrieval or reconsolidation of contextual fear memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 134, Part B, October 2016, Pages 287-293
نویسندگان
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