کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5043354 1475139 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
ترجمه فارسی عنوان
اختلاف سنی در بیان و تیرگی آموخته شده شامل نوسانات گاما تغییر یافته در قشر مدرن پیش فرنتن است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- We examined sex differences in auditory fear memory expression and extinction in rats.
- During behaviour we examined gamma oscillations in prelimbic and infralimbic cortex.
- Females showed enhanced learned fear expression linked to elevated prelimbic gamma.
- Females also showed impaired extinction retrieval linked to reduced infralimbic gamma.

Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female rats. Emerging evidence indicates that gamma oscillations in mPFC are also implicated in the expression and extinction of learned fear. Therefore we re-examined our in vivo electrophysiology data and found that females showed persistent PL gamma activation during extinction and a failure of IL gamma activation during extinction recall. Altered prefrontal gamma oscillations thus accompany sex differences in learned fear expression and its extinction. These findings are relevant for understanding the neural basis of post-traumatic stress disorder, which is more prevalent in women and involves impaired extinction and mPFC dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 135, November 2016, Pages 66-72
نویسندگان
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