کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5043566 1475295 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI
چکیده انگلیسی


- Resting state functional MRI studies is a promising non-invasive tool for better understanding of the pathophysiology of sleep disorders.
- The salience network is involved in hyperarousal and affective symptoms in insomnia.
- The posterior default mode network appears to underlie cognitive and depressive symptoms of obstructive sleep apnoea.
- Disruption of intrinsic networks have been demonstrated in major depression, which is a common co-morbidity of sleep disorders.

Functional neuroimaging techniques have accelerated progress in the study of sleep disorders. Considering the striking prevalence of these disorders in the general population, however, as well as their strong bidirectional relationship with major neuropsychiatric disorders, including major depressive disorder, their numbers are still surprisingly low. This review examines the contribution of resting state functional MRI to current understanding of two major sleep disorders, insomnia disorder and obstructive sleep apnoea. An attempt is made to learn from parallels of previous resting state functional neuroimaging findings in major depressive disorder. Moreover, shared connectivity biomarkers are suggested for each of the sleep disorders. Taken together, despite some inconsistencies, the synthesis of findings to date highlights the importance of the salience network in hyperarousal and affective symptoms in insomnia. Conversely, dysfunctional connectivity of the posterior default mode network appears to underlie cognitive and depressive symptoms of obstructive sleep apnoea.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 77, June 2017, Pages 219-231
نویسندگان
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