Binary conjugate Brønsted–Lewis acid supported on mesoporous silica nanoparticles for the domino addition/elimination/addition and addition/elimination/addition/cyclization cascade

• Synthesis of 25–30 nm size mesoporous silica nanoparticle supported HBF4 catalyst
• Clean and rapid synthesis of tetraketones or the enol forms at room temperature
• Conversion of tetraketones to xanthenes

Fluoroboric acid (HBF4) adsorbed on mesoporous silica nanoparticles of 25–30 nm dimension was synthesized and characterized by N2 adsorption, HRTEM, EDX, XPS, XRD, 29Si MAS NMR etc. The applicability of silica-HBF4 was probed through a library synthesis of tetraketones or their tautomeric enol forms. These tetraketones are further transformed into xanthenes. Synthesis using aqueous-ethanol is of paramount importance for its sustainable green impact.

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