کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5045255 1475561 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pseudoneglect in line bisection judgement is associated with a modulation of right hemispheric spatial attention dominance in right-handers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Pseudoneglect in line bisection judgement is associated with a modulation of right hemispheric spatial attention dominance in right-handers
چکیده انگلیسی


- Line bisection judgement (LBJ) induced a leftward spatial deviation bias.
- LBJ elicited occipito-parieto-frontal rightward asymmetries.
- Cerebral lateralization was related to LBJ deviation bias.
- LBJ asymmetries are consistent with lesions map of line bisection impaired patients.
- LBJ is adequate to investigate the variability of spatial lateralization.

The objective of this study was to validate a line bisection judgement (LBJ) task for use in investigating the lateralized cerebral bases of spatial attention in a sample of 51 right-handed healthy participants. Using functional magnetic resonance imaging (fMRI), the participants performed a LBJ task that was compared to a visuomotor control task during which the participants made similar saccadic and motoric responses. Cerebral lateralization was determined using a voxel-based functional asymmetry analysis and a hemispheric functional lateralization index (HFLI) computed from fMRI contrast images. Behavioural attentional deviation biases were assessed during the LBJ task and a “paper and pencil” symbol cancellation task (SCT). Individual visuospatial skills were also evaluated. The results showed that both the LBJ and SCT tasks elicited leftward spatial biases in healthy subjects, although the biases were not correlated, which indicated their independence. Neuroimaging results showed that the LBJ task elicited a right hemispheric lateralization, with rightward asymmetries found in a large posterior occipito-parietal area, the posterior calcarine sulcus (V1p) and the temporo-occipital junction (TOJ) and in the inferior frontal gyrus, the anterior insula and the superior medial frontal gyrus. The comparison of the LBJ asymmetry map to the lesion map of neglect patients who suffer line bisection deviation demonstrated maximum overlap in a network that included the middle occipital gyrus (MOG), the TOJ, the anterior insula and the inferior frontal region, likely subtending spatial LBJ bias. Finally, the LBJ task-related cerebral lateralization was specifically correlated with the LBJ spatial bias but not with the SCT bias or with the visuospatial skills of the participants. Taken together, these results demonstrated that the LBJ task is adequate for investigating spatial lateralization in healthy subjects and is suitable for determining the factors underlying the variability of spatial cerebral lateralization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 94, 8 January 2017, Pages 75-83
نویسندگان
, , , , , , , ,