کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5045312 1370661 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sequence learning in Parkinson's disease: Focusing on action dynamics and the role of dopaminergic medication
ترجمه فارسی عنوان
یادگیری توالی در بیماری پارکینسون: تمرکز بر پویایی عمل و نقش داروهای دوپامینرژیک
کلمات کلیدی
بیماری پارکینسون، یادگیری ترتیب جنبش، دوپامین، ردیابی ماوس،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- We studied the action dynamics of sequence learning in Parkinson's disease.
- The effects of dopaminergic medication on mouse movements were considered.
- Medication enhanced sequence learning as reflected in initiation time.
- Conversely, it impaired sequence learning as reflected in movement accuracy.
- These findings are discussed in light of the dopamine overdose hypothesis.

Previous studies on movement sequence learning in Parkinson's disease (PD) have produced mixed results. A possible explanation for the inconsistent findings is that some studies have taken dopaminergic medication into account while others have not. Additionally, in previous studies the response modalities did not allow for an investigation of the action dynamics of sequential movements as they unfold over time. In the current study we investigated sequence learning in PD by specifically considering the role of medication status in a sequence learning task where mouse movements were performed. The focus on mouse movements allowed us to examine the action dynamics of sequential movement in terms of initiation time, movement time, movement accuracy, and velocity. PD patients performed the sequence learning task once on their regular medication, and once after overnight withdrawal from their medication. Results showed that sequence learning as reflected in initiation times was impaired when PD patients performed the task ON medication compared to OFF medication. In contrast, sequence learning as reflected in the accuracy of movement trajectories was enhanced when performing the task ON compared to OFF medication. Our findings suggest that while medication enhances execution processes of movement sequence learning, it may at the same time impair planning processes that precede actual execution. Overall, the current study extends earlier findings on movement sequence learning in PD by differentiating between various components of performance, and further refines previous dopamine overdose effects in sequence learning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 93, Part A, December 2016, Pages 30-39
نویسندگان
, , , , , ,