کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
505119 | 864474 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discrimination of malignant neutrophils of chronic myelogenous leukemia from normal neutrophils by support vector machine
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کلمات کلیدی
BCR, breakpoint cluster region - BCR، منطقه خالص نقطه توقفCML, chronic myelogenous leukemia - CML، لوسمی مزمن میلوئیدیSVM, support vector machine - SVM، دستگاه بردار پشتیبانی می کندROC, receiver operating characteristic - منحنی مشخصه عملکرد سیستمPCR, polymerase chain reaction - واکنش زنجیرهٔ پلیمراز
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discrimination of malignant neutrophils of chronic myelogenous leukemia from normal neutrophils by support vector machine Discrimination of malignant neutrophils of chronic myelogenous leukemia from normal neutrophils by support vector machine](/preview/png/505119.png)
چکیده انگلیسی
Malignant neutrophils of chronic myelogenous leukemia (CML) have similar antigen expression patterns compared to their normal counterparts, thus making the cells difficult to distinguish by clinical flow cytometry. In this study, we applied the support vector machine method to build a malignant neutrophil prediction model based on nine CML patients and nine healthy donors. This approach effectively differentiated between malignant and normal neutrophils with high specificity and sensitivity (≤95.80% and ≤95.30%, respectively). This approach may broaden the application of flow cytometry for differentiation between CML and normal neutrophils and become an important diagnostic tool in CML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 43, Issue 9, 1 September 2013, Pages 1192–1195
Journal: Computers in Biology and Medicine - Volume 43, Issue 9, 1 September 2013, Pages 1192–1195
نویسندگان
Wanmao Ni, Xiangmin Tong, Wenbin Qian, Jie Jin, Hongchan Zhao,