Di-n-butyl ammonium chlorosulfonate as a highly efficient and recyclable ionic liquid for the synthesis of N-containing bisphosphonates

• Novel di-n-butyl ammonium ionic liquid (DBA IL) is synthesized and well characterized.
• The DBA IL is an admirable organocatalyst for the synthesis of N-containing bisphosphonates
• N-containing bisphosphonates are obtained in good yields at eco-friendly conditions.
• The DBA IL catalyst is recyclable without losing its catalytic activity up to four cycles.

The preparation and description of a novel secondary amine ionic liquid, di-n-butyl ammonium chlorosulfonate, is described. The di-n-butyl ammonium ionic liquid (DBA IL) was characterized by FT-IR, elemental analysis, NMR spectroscopies, and wide-angle X-ray scattering techniques, as well as thermogravimetric analysis. The DBA IL functions as an efficient, environmentally benign, and recyclable catalyst with short reaction times and high catalytic activity for the synthesis of a variety of N-containing bisphosphonates in high yields. Another merit of this ionic liquid shown that the purification of products by non-chromatographic method with good to excellent yields of the desired products.

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