کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5102599 | 1480087 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of the fluctuations of the tumour/host interface
ترجمه فارسی عنوان
تجزیه و تحلیل نوسانات رابط تومور / میزبان
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
چکیده انگلیسی
In a recent analysis of metabolic scaling in solid tumours we found a scaling law that interpolates between the power laws μâV and μâV2â3, where μ is the metabolic rate expressed as the glucose absorption rate and V is the tumour volume. The scaling law fits quite well both in vitro and in vivo data, however we also observed marked fluctuations that are associated with the specific biological properties of individual tumours. Here we analyse these fluctuations, in an attempt to find the population-wide distribution of an important parameter (A) which expresses the total extent of the interface between the solid tumour and the non-cancerous environment. Heuristic considerations suggest that the values of the A parameter follow a lognormal distribution, and, allowing for the large uncertainties of the experimental data, our statistical analysis confirms this.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 486, 15 November 2017, Pages 587-594
Journal: Physica A: Statistical Mechanics and its Applications - Volume 486, 15 November 2017, Pages 587-594
نویسندگان
Edoardo Milotti, Vladislav Vyshemirsky, Sabrina Stella, Federico Dogo, Roberto Chignola,