کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5102894 1480102 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stochastic resonance, coherence resonance, and spike timing reliability of Hodgkin-Huxley neurons with ion-channel noise
ترجمه فارسی عنوان
رزونانس تصادفی، رزونانس انسجام و اعتبار زمان بندی نورون هاجکین-هاکسلی با نویز کانال یون
کلمات کلیدی
نویز کانال کانال خوشه های خود به خودی، رزونانس تصادفی، قابلیت اطمینان زمان بندی سنبله،
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی
The random transitions of ion channels between open and closed states are a major source of noise in neurons. In this study, we investigate the stochastic dynamics of a single Hodgkin-Huxley (HH) neuron with realistic, physiological channel noise, which depends on the channel number and the voltage potential of the membrane. Without external input, the stochastic HH model can generate spontaneous spikes induced by ion-channel noise, and the variability of inter-spike intervals attains a minimum for an optimal membrane area, a phenomenon known as coherence resonance. When a subthreshold periodic input current is added, the neuron can optimally detect the input frequency for an intermediate membrane area, corresponding to the phenomenon of stochastic resonance. We also investigate spike timing reliability of neuronal responses to repeated presentations of the same stimulus with different realizations of channel noise. We show that, with increasing membrane area, the reliability of neuronal response decreases for subthreshold periodic inputs, and attains a minimum for suprathreshold inputs. Furthermore, Arnold tongues of high reliability arise in a two-dimensional plot of frequency and amplitude of the sinusoidal input current, resulting from the resonance effect of spike timing reliability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 471, 1 April 2017, Pages 263-275
نویسندگان
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