کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5120508 1486124 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running
ترجمه فارسی عنوان
خودکشی کوکائین و بازگرداندن آن در موش های صحرایی به طور انتخابی برای انجام داوطلبانه بالا و پایین پرورش می یابد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Rats bred for High and Low Voluntary Running (HVR/LVR) self-administered cocaine.
- LVRs acquired cocaine use faster and persisted in drug seeking longer upon extinction.
- Once acquired, few differences in cocaine self-administration were observed.
- LVRs were more vulnerable to cocaine seeking than HVRs during transition periods.

BackgroundPrevious research has found that rats behaviorally screened for high (vs. low) wheel running were more vulnerable to cocaine abuse. To assess the extent to which a genetic component is involved in this drug-abuse vulnerability, rats selectively bred for high or low voluntary running (HVR or LVR, respectively) were examined for differences in cocaine seeking in the present study.MethodsFemale rats were trained to lever press for food and then were assessed for differences in acquisition of cocaine (0.4 mg/kg; i.v.) self-administration across 10 sessions. Once acquired, rats self-administered cocaine for a 14-day maintenance phase, followed by a 14-day extinction phase when cocaine was no longer available. Subsequently, reinstatement of cocaine seeking was examined with priming injections of cocaine (5, 10 & 15 mg/kg), caffeine (30 mg/kg), yohimbine (2.5 mg/kg) and cocaine-paired cues.ResultsA greater percentage of LVR rats met the acquisition criteria for cocaine self-administration and in fewer sessions than HVR rats. No differences in responding for cocaine were observed between phenotypes during maintenance. However, during extinction LVR rats initially responded at higher rates and persisted in cocaine seeking for a greater number of sessions. No phenotype differences were observed following drug and cue-primed reinstatement of cocaine seeking.ConclusionsIn general, LVR rats were more sensitive to the reinforcing effects of cocaine than HVR rats during periods of transition into and out of cocaine self-administration. Thus, LVR rats sometimes showed a greater vulnerability cocaine seeking than HVR rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 167, 1 October 2016, Pages 163-168
نویسندگان
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