کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5121848 | 1486845 | 2017 | 7 صفحه PDF | دانلود رایگان |
ObjectivesTo introduce a new analytic approach for matched studies, where exactly two controls are linked to each case (double controls rather than solitary controls). The intent is to extend McNemar's test for one-to-two matching (instead of one-to-one matching) when evaluating binary predictors and outcomes.Study Design and SettingWe review McNemar's approach for analyzing matched data, demonstrate the Mantel-Haenszel approach for integrating two overlapping McNemar's estimates, review conditional logistic regression as an alternative analytic approach, and introduce a new method that yields a visual display and easy verification.ResultsWe illustrate the new approach with real data testing the association between overcast weather and the risk of a life-threatening traffic crash (n = 6,962). We show that results from the new approach agree closely with conditional logistic regression and are sufficiently simple as to be computed on a handheld calculator. We further validate the approach by conducting simulations when a positive association was predefined and when a null association was predefined.ConclusionThe new approach provides a feasible, simple, and efficient method for analyzing matched designs with double controls.
Journal: Journal of Clinical Epidemiology - Volume 81, January 2017, Pages 51-55.e2