A practical and benign synthesis of amines through Pd@mpg-C3N4 catalyzed reduction of nitriles

Liquid phase hydrogenation of nitriles is an important method for the production of amines, which find a variety of applications as intermediates in chemical and pharmaceutical industry. In the present work, a highly efficient Pd@mpg-C3N4 catalytic system has been developed for chemoselective reduction of nitriles providing good to excellent conversion with remarkable chemoselectivity (up to 99%) without additives. Compared with homogeneous catalyst systems, the developed protocol is more advantageous due to the use of ambient hydrogen, solvent free and effective catalyst recyclability.

A highly efficient Pd@mpg-C3N4 catalytic system has been developed for chemoselective reduction of nitriles providing good to excellent conversion with remarkable chemoselectivity (up to 100%) without additives. Compared with homogeneous catalyst systems, the developed protocol is more advantageous due to use of ambient hydrogen, solvent free and effective catalyst recyclability.Figure optionsDownload as PowerPoint slideHighlights
► Selective hydrogenation of nitriles were realized under mild conditions.
► We developed the novel, active Pd@mpg-C3N4 for this process.
► This system affords high activity and selectivity under mild conditions.
► These catalysts possess good reusability.