کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5123775 | 1487582 | 2017 | 7 صفحه PDF | دانلود رایگان |
AimsConsidering the protective role of adiponectin, we aimed to investigate the impact of different levels of adiponectin on biomarkers of inflammation among adolescents with obesity.MethodsWere recruited 220 post-pubertal adolescents with obesity. Body composition, lipid profile, adiponectin and leptin concentrations were obtained. Adolescents were distributed in 3 groups (lower levels of adiponectin â¤4.85; medium levels of adiponectin >4.85 e â¤Â 9.63; higher levels of adiponectin >9.63). GLM test was performed to analyze difference between groups with p level set at â¤0.05. Pathway analyze was performed.ResultsThe most important find in the present low tertile has higher values of body fat compared to medium values. Interesting, insulin(μU/mL), HOMA -AD, total cholesterol (mg/dL), LDL, VLDL, Triglycerides (mg/dL), leptin and leptin/adiponectin ratio presented statistical higher values; inversely; QUICKI, HDL, and adiponectin/leptin ratio has lower when compared low with higher tertile. Analyzing the adiponectin pathway, the comportment of adiponectin was partially mediated by negative correlation with leptin/adiponectin ratio, HOMA-AD and HOMA-IR and positive correlation with HDL-col.ConclusionTogether, these results may partly contribute to explain the role of adiponectin linking obesity whit atherosclerosis, as depended dose-response of this hormone concentration once in the lower tertile of adiponectin these results were not showed.
Journal: Obesity Medicine - Volume 5, March 2017, Pages 4-10