کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
51258 46836 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective epoxidation of curcumol and curdione by Cunninghamella elegans AS 3.2028
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Stereoselective epoxidation of curcumol and curdione by Cunninghamella elegans AS 3.2028
چکیده انگلیسی

Sesquiterpenes such as curcumol (1) and curdione (2) are the major ingredients of Rhizoma curcumae. Compounds (1) and (2) are isomers of one another and play important roles in Chinese Traditional Medicine. Microbial transformations of naturally occurring curcumol and curdione by Cunninghamella elegans AS 3.2028 were studied. In this research, stereoselective epoxidation at the double bond of curcumol led to 10S,14-epoxycurcumol (3) as the major metabolite, with no detectable 10R,14-epoxycurcumol (4). Epoxidation also occurred at the double bond of curdione, generating both (1S,10S)- and (1R,10R)-1,10-epoxycurdione (5) and (6). The diastereomeric excess (de) of the S diastereomer was 27%. The selectivity of the biotransformation is discussed.

Graphic abstractFigure optionsDownload as PowerPoint slideHighlights
► Biotransformations of curcumol and curdione by C. elegans AS 3.2028 are reported.
► Selective epoxidation at the double bond of curcumol and curdione was studied.
► The selectivity of the epoxidation biotransformation is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Catalysis Communications - Volume 28, 5 November 2012, Pages 191–195
نویسندگان
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