Ultrasonic-assisted extraction and dispersive liquid-liquid microextraction combined with gas chromatography-mass spectrometry as an efficient and sensitive method for determining of acrylamide in potato chips samples

- We developed a new method to determine of acrylamide from potato chips samples.
- Ultrasonic-assisted extraction was used to release of acrylamide from potato chips.
- A new derivatization method enhances recovery, separation and detectability.
- Use of xanthydrol as a new derivatizing agent was achieved highly efficient.
- Derivatization combined with UAE-DLLME simplified experimental procedure.
- The increased sensitivity in use the UAE-DLLME-GC-MS method has been demonstrated.

In this research, for the first time, we successfully developed ultrasonic-assisted extraction and dispersive liquid-liquid microextraction combined with gas chromatography-mass spectrometry as a new, fast and highly sensitive method for determining of acrylamide in potato chips samples. Xanthydrol was used as a derivatization reagent and parameters affecting in the derivatization and microextraction steps were studied and optimized. Under optimum conditions, the calibration curves showed high levels of linearity (R2 > 0.9993) for acrylamide in the range of 2-500 ng mL−1. The relative standard deviation (RSD) for the seven analyses was 6.8%. The limit of detection (LOD) and limit of quantification (LOQ) were 0.6 ng g−1 and 2 ng g−1, respectively. The UAE-DLLME-GC-MS method demonstrated high sensitivity, good linearity, recovery, and enrichment factor. The performance of the new proposed method was evaluated for the determination of acrylamide in various types of chips samples and satisfactory results were obtained.