کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5133767 | 1492071 | 2017 | 6 صفحه PDF | دانلود رایگان |
- Selective oxidation of zerumbone to an aldehyde and a ketone with added conjugated-carbonyl-functionality is discovered.
- Zerumbal and zerumbenone exhibited strong antimutagenic activity and good antibacterial activity.
- An important perspective of the new derivatives is outlined.
Synthesis of new zerumbone-bicarbonyl analogues by SeO2 oxidation is reported. Selective oxidation of methyl at C-13 to an aldehyde and a ketone with exo-cyclic double bond between C-13 and C-6 in zerumbone has been recognized. Both these compounds have an additional conjugated-carbonyl-functionality. They exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester strains. They are more active against Gram positive bacteria than Gram negative bacteria; however zerumbone showed highest activity against E. coli, whereas its derivatives were least effective against E. coli.
Journal: Food Chemistry - Volume 221, 15 April 2017, Pages 576-581