The nature of hydrogen-bonding interactions in nonsteroidal anti-inflammatory drugs revealed by polarized IR spectroscopy

A combined polarization-dependent IR spectroscopy and the H/D exchange technique have been used to characterize the inter‑hydrogen bond interaction nature in selected nonsteroidal anti-inflammatory drugs. The presented spectral results show a correlation between the way of hydrogen bonding association of the carboxyl groups of selected drugs and their vOH band structure patterns.289