کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5142069 1496022 2017 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro cytotoxic and antioxidant activities of phenolic components of Algerian Achillea odorata leaves
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
In vitro cytotoxic and antioxidant activities of phenolic components of Algerian Achillea odorata leaves
چکیده انگلیسی
In this study, methanol extract from Achillea odorata was evaluated for its phenolic contents using Folin-Ciocalteu reagent, and antioxidant activity using: 1,1-diphenyl-2-picrylhidrazyl (DPPH) radical scavenging activity, reducing activity of H2O2 and ferric reducing power assay. The total phenolic content was determined as gallic acid (GAE) equivalent. Flavonoids and flavonols contents were determined as quercetin (QE) equivalents. The cytotoxicity of the plant extract was tested against three tumor cell lines: MCF-7, Hep2 and WEHI using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphynyl tetrazolium bromide (MTT) assay. Preliminary screening was concluded in the presence of substances with large therapeutic values. The total phenolic content confirmed the presence of total phenolics in the extract and showed strong association with antioxidant activity. An important content of flavonoids and flavonols was also detected. The results of the antioxidant activities obtained indicate that A. odorata recorded a good capacity. For the cytotoxic activity, the results showed the plant extract significantly inhibited tumor cell growth and colony formation at various concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Issue 3, March 2017, Pages 403-409
نویسندگان
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