کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5142127 1496026 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermal analysis study of antihypertensive drug doxazosin mesilate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Thermal analysis study of antihypertensive drug doxazosin mesilate
چکیده انگلیسی
Thermogravimetry and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as stability, purity and formulation compatibility among others. The present work reports studies of the thermal behavior of antihypertensive drug doxazosin mesilate as raw material and in the form of tablets. The purity was determined by DSC and specialized pharmacopeial method. Analysis of the DSC data indicated that the degree of purity of doxazosin mesilate was similar to that found by the official HPLC method used in the British pharmacopoeia, BP 2011. The simplicity and sensitivity of thermal analysis justify its application in the quality control of pharmaceutical compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 10, Supplement 1, February 2017, Pages S334-S338
نویسندگان
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