کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142454 | 1496034 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physiological significance of Fuc and Sialic acid containing glycans in the body
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کلمات کلیدی
Sialyl-LexGT1GD2GT1bN-acetylgalactosamineGalNAcLacNAcGD1bGM1Neu5GcGlcNAcGlcLacdiNAcFucoseFucNeuraminic acid - اسید نوریامینیکneu - جدیدCer - سرceramide - سرامیدSialic acid - سیالیک اسیدCellular physiology - فیزیولوژی سلولیMannose - مانوزMan - مردComplex carbohydrates - کربوهیدرات های پیچیدهGal - گالGalactose - گالاکتوزمی Glucose - گلوکز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Complex biomolecular machinery carrying diverse glycan chains are involved in a wide range of physiological activities including blood group determination, cancer recognition protein stabilization and sperm-egg interaction. Diversity of glycan chains, linked to lipids and proteins is due to isomeric and conformational modifications of various sugar residues, giving rise to unique carbohydrate structures with a wide range of anomeric linkages. This unique and significant structural diversity of naturally occurring oligosaccharide structures make them the best recognition markers for countless physiological activities. This is a challenging task to explore the relationship between biological processes and stereochemical behavior of sugar residues. Current review article is related with the physiological significance of glycans carrying fucose and/or sialic residues in complex biomolecular assemblies. Both the sugar units have a diverse range of anomery and linkages with the penultimate sugars. The existing literature and databases did not contain comprehensive information regarding structure-function relationship of glycans. Therefore, the current study is scheduled to debate on the structure-function relationship of glycans carrying Fuc and sialic acid in their backbone structures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S9-S20
Journal: Arabian Journal of Chemistry - Volume 9, Supplement 1, September 2016, Pages S9-S20
نویسندگان
Muhammad Ramzan Manwar Hussain, Nasirud Din, Mukhtarul Hassan, Abdul Razaq, Zeeshan Iqbal,