Synthesis and biological evaluation of 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives

A series of novel 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives designed and synthesized. They were exhibited moderate to strong fungicidal activity against six fungi in vitro at 50 μg/mL, and some of them presented good curative activity against TMV in vivo at 500 μg/mL.