کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142943 | 1379132 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Novel 1,2,3-triazin-4-one derivatives incorporating 4-thiazolidinone moieties were designed and synthesized. Many of them exhibited moderate to good inhibitory activity against LTA4H aminopeptidase at 10 μmol/L, the compound IV-16 with best bioactivity was also tested the proliferation inhibitory activities in THP1 human AML cell line and its binding model with LTA4H enzyme by molecular docking was studied. It indicated that 1,2,3-triazin-4-one was a very promising scaffold to study further.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 28, Issue 5, May 2017, Pages 1044-1048
Journal: Chinese Chemical Letters - Volume 28, Issue 5, May 2017, Pages 1044-1048
نویسندگان
Fan Zhang, Dang Wu, Gao-Lei Wang, Shuang Hou, Ping Ou-Yang, Jin Huang, Xiao-Yong Xu,