کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5142943 1379132 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
چکیده انگلیسی
Novel 1,2,3-triazin-4-one derivatives incorporating 4-thiazolidinone moieties were designed and synthesized. Many of them exhibited moderate to good inhibitory activity against LTA4H aminopeptidase at 10 μmol/L, the compound IV-16 with best bioactivity was also tested the proliferation inhibitory activities in THP1 human AML cell line and its binding model with LTA4H enzyme by molecular docking was studied. It indicated that 1,2,3-triazin-4-one was a very promising scaffold to study further.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 28, Issue 5, May 2017, Pages 1044-1048
نویسندگان
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