In situ-prepared homogeneous supramolecular organic framework drug delivery systems (sof-DDSs): Overcoming cancer multidrug resistance and controlled release

Supramolecular organic framework drug delivery systems (sof-DDSs) have been developed as loading-free porous nanocarriers, which enable efficient delivery of pemetrexed, an anti-cancer chemotherapeutic agent, into multidrug-resistant human breast cancer cells and the acidic medium-responsive drug release.