کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5151256 | 1498912 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dimethyltin(IV) and palladium(II) complexes derived from 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone: Synthesis, crystal structures and biological evaluation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two metal complexes [(Me)2Sn(L)(OAc)] (1), and [Pd(L)Cl] (2) based on 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone have been synthesized and structurally characterized. Growth inhibition assays have indicated that two compounds can effectively inhibit the growth of HepG2 cancer cell lines at micromolar concentrations. In addition, apoptosis mechanisms of 2 on HepG2 cells were further investigated. The results show that 2 can promote the apoptosis of HepG2 cells and the apoptosis is associated with the activation of caspase-3.234
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganic Chemistry Communications - Volume 78, April 2017, Pages 65-69
Journal: Inorganic Chemistry Communications - Volume 78, April 2017, Pages 65-69
نویسندگان
Yuan-Yuan Wu, Yu-Ting Wang, Ying-Ying Wang, Ming-Xue Li, Yan-Li Lu, Ya-Hong Zhang,