Synthesis of novel ethyl 2,4-disubstituted 8-(trifluoromethyl)pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine-9-carboxylate derivatives as promising anticancer agents

A series of novel pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine derivatives were prepared, screened for anticancer activity against five human cancer cell lines and promising compounds were identified.99