کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5155570 1379493 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems
چکیده انگلیسی
New phenylpiperazine derivatives were synthesized and evaluated for binding to adrenergic receptors, α1-adrenolytic properties in vitro and hypotensive activity in vivo. 1-[4-(2,6-dimethylphenoxy)butyl]-4-(2-methoxyphenyl)piperazine hydrochloride possessed the most beneficial pharmacological profile. Structure-activity relationship for the tested compounds was discussed.56
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 21, 1 November 2016, Pages 5315-5321
نویسندگان
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