Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems

New phenylpiperazine derivatives were synthesized and evaluated for binding to adrenergic receptors, α1-adrenolytic properties in vitro and hypotensive activity in vivo. 1-[4-(2,6-dimethylphenoxy)butyl]-4-(2-methoxyphenyl)piperazine hydrochloride possessed the most beneficial pharmacological profile. Structure-activity relationship for the tested compounds was discussed.56