Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases

Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 22, 15 November 2016, Pages 5476-5480

Courtney R. Kent, Magdalena Bryja, Helen A. Gustafson, Margaret Y. Kawarski, Gena Lenti, Emily N. Pierce, Rachel C. Knopp, Victor Ceja, Bhabna Pati, D. Eric Walters, Caitlin E. Karver,