Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 19, 1 October 2016, Pages 4775-4780

Chungang Gu, Michelle L. Lamb, Jeffrey W. Johannes, Mark A. Sylvester, Mark S. Eisman, Rane A. Harrison, Haiqing Hu, Steven Kazmirski, Keith Mikule, Bo Peng, Nancy Su, Wenxian Wang, Qing Ye, Xiaolan Zheng, Paul D. Lyne, David A. Scott,