The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists

The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 19, 1 October 2016, Pages 4781-4784

Jason C. Rech, Anindya Bhattacharya, Bryan J. Branstetter, Christopher J. Love, Joseph E. Leenaerts, Ludwig P. Cooymans, William A. III, Hong Ao, Qi Wang, Sandra R. Chaplan, Alan D. Wickenden, Alec D. Lebsack, J. Guy Breitenbucher,