A dioxidovanadium (V) complex of NNO-donor Schiff base as a selective inhibitor of protein tyrosine phosphatase 1B: Synthesis, characterization, and biological activities

A new dioxidovanadium (V) complex (1) has been synthesized and characterized. It potently and selectively inhibited protein tyrosine phosphatase 1B, increased the phosphorylation of PTP1B substrates and exhibited lower cytotoxicity than VOSO4, suggesting a promising candidate for novel vanadium-based anti-diabetic drug.240