ZnO nanofluid as a structure base catalyst for chemoselective amidation of aliphatic carboxylic acids

ZnO nanofluids were synthesized and utilized as a new reaction media in the preparation of amides via direct amidation of aliphatic carboxylic acids with primary amines under solvent-free conditions. High yields and good selectivity are achieved with this psudo-homogeneous catalyst, while the recovered nanoZnO was reusable.

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► ZnO nanofluids were originally used as catalyst in the amidation of acids.
► The amount of fluid is important for ZnO nanofluids.
► ZnO nanofluid can be easily prepared and is reusable.
► Aliphatic acids were reacted chemoselectively versus aromatic ones.