A catalytic method for synthesis of 6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4[5H]-ones by heteropolyacids: H14[NaP5W29MoO110] and H3PMo12O40

Derivatives of 6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4[5H]-ones 4, are synthesized from reaction of 5-amino-1-phenyl-1H-pyrazolo-4-carboxamide 1 with aromatic aldehyde in the presence of heteropolyacids, H3PMo12O40, H3-PMo, and H14[NaP5W29MoO110], H14P5-Mo with high yields. The catalytic activity of H3-PMo is found to be lower than H14P5-Mo.