کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5292 | 362 | 2011 | 14 صفحه PDF | دانلود رایگان |
Two types of analytical microsystems for the detection of species of interest in biomedical diagnosis and in environmental monitoring are specifically described in this paper. We describe a novel device that will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity and that will then offer opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/ micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold, enabling diagnostics at the point-of-first-contact.The feasibility of a generic microsytem integrating a microfluidic system of concentration and a module of electrochemical detection is demonstrated for the four metals of the European directive (DCE 2000/60/EC) for the quality of water resource: cadmium, mercury, lead and nickel.
Journal: Biocybernetics and Biomedical Engineering - Volume 31, Issue 4, 2011, Pages 3–16