کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5350265 1503659 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioactivity and osteogenic cell response of TiO2 nanotubes coupled with nanoscale calcium phosphate via ultrasonification-assisted electrochemical deposition
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Bioactivity and osteogenic cell response of TiO2 nanotubes coupled with nanoscale calcium phosphate via ultrasonification-assisted electrochemical deposition
چکیده انگلیسی
Ultrasonification-assisted electrochemical deposition was used to introduce nanoscale calcium phosphate (CaP) into well-ordered TiO2 nanotube arrays (NTA) fabricated by anodic oxidation. Field emission scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and a drop-shape analysis system were used to investigate the morphology, constituent components and hydrophilicity of the nanostructured CaP/NTA surface. Bioactivity and osteogenic cell response were also characterized by hydroxyapatite (HA) formation tests, protein adsorption tests, and in vitro preosteoblast culture experiments. Abundant acicular nanoscale calcium phosphate was successfully deposited on the inner and outer walls of the nanotubes. After immersion in simulated body fluid, increased hydroxyapatite formation was apparent on the surface of TiO2 nanotubes coupled with nanoscale CaP when compared to simple nanotube structures and polished titanium. The CaP/NTA surface also adsorbed a greater amount of protein after being exposed to bovine serum albumin solution. During cell culture experiments, the preosteoblasts exhibited enhanced cellular adhesion, proliferation, and differentiation on the CaP/NTA surfaces. The results demonstrate that the introduction of nanoscale calcium phosphate into self-organized TiO2 nanotubes via a straightforward ultrasonification-assisted deposition technique enhances the bioactivity and osteogenic cell response, owing to the combined effects of the nanostructured surface topography, chemical composition, and hydrophilicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 305, 30 June 2014, Pages 24-32
نویسندگان
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