کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5354 367 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy
ترجمه فارسی عنوان
انتشار موضعی اختصاصی ترشح موضعی یک عامل شیمی درمانی و یک دارو ضد سرطان در یک روش قابل کنترل زمان جهت افزایش اثربخشی درمانی
کلمات کلیدی
انتشار مواد مخدر، شیمی درمانی ترکیبی، گونه های اکسیژن واکنش پذیر، عامل شیمیایی، اثرات ضد سرطانی هم افزایی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

Combination chemotherapy with multiple drugs commonly requires several injections on various schedules, and the probability that the drug molecules reach the diseased tissues at the proper time and effective therapeutic concentrations is very low. This work elucidates an injectable co-delivery system that is based on cationic liposomes that are adsorbed on anionic hollow microspheres (Lipos-HMs) via electrostatic interaction, from which the localized sequence-specific release of a chemopreventive agent (1,25(OH)2D3) and an anticancer drug (doxorubicin; DOX) can be thermally driven in a time-controllable manner by an externally applied high-frequency magnetic field (HFMF). Lipos-HMs can greatly promote the accumulation of reactive oxygen species (ROS) in tumor cells by reducing their cytoplasmic expression of an antioxidant enzyme (superoxide dismutase) by 1,25(OH)2D3, increasing the susceptibility of cancer cells to the cytotoxic action of DOX. In nude mice that bear xenograft tumors, treatment with Lipos-HMs under exposure to HFMF effectively inhibits tumor growth and is the most effective therapeutic intervention among all the investigated. These empirical results demonstrate that the synergistic anticancer effects of sequential release of 1,25(OH)2D3 and DOX from the Lipos-HMs may have potential for maximizing DOX cytotoxicity, supporting more effective cancer treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 101, September 2016, Pages 241–250
نویسندگان
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