Wettability and osteoblast cell response modulation through UV laser processing of nylon 6,6

► Surface modifications brought about variations in surface oxygen and topography. ► Laser-modified surface properties modulated wettability. ► Wettability differed between samples indicating a mixed-state wetting regime. ► The bioactivities of the samples were modulated with evidence of differentiation. ► Correlations have been identified between surface properties and cell response.