کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5357342 | 1503616 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Photodynamic therapy using upconversion nanoparticles prepared by laser ablation in liquid
ترجمه فارسی عنوان
درمان فوتودینامیک با استفاده از نانوذرات تبدیل شده توسط لیزر در مایع انجام می شود
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
Upconversion nanoparticles were prepared by laser ablation in liquid, and the potential use of the nanoparticles for cancer treatment was investigated. A Nd:YAG/SHG laser (532Â nm, 13Â ns, 10Â Hz) was used for ablation, and the cancer treatment studied was photodynamic therapy (PDT). Morphology and crystallinity of prepared nanoparticles were examined by transmission electron microscopy and X-ray diffraction. Red and green emissions resulting from near-infrared excitation were observed by a fluorescence spectrophotometer. Generation of singlet oxygen was confirmed by a photochemical method using 1,3-diphenylisobenzofuran (DPBF). In vitro experiments using cultivated cancer cells were conducted to investigate PDT effects. Uptake of the photosensitizer by cancer cells and cytotoxicities of cancer cells were also examined. We conclude that the combination of PDT and highly crystalline nanoparticles, which were prepared by laser ablation in liquid, is an effective cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 348, 1 September 2015, Pages 54-59
Journal: Applied Surface Science - Volume 348, 1 September 2015, Pages 54-59
نویسندگان
Tomohiro Ikehata, Yuji Onodera, Takashi Nunokawa, Tomohisa Hirano, Shun-ichiro Ogura, Toshiaki Kamachi, Osamu Odawara, Hiroyuki Wada,