کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5359134 1388243 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
X-ray photoelectron spectroscopic investigations of modifications in plasmid DNA after interaction with Hg nanoparticles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
X-ray photoelectron spectroscopic investigations of modifications in plasmid DNA after interaction with Hg nanoparticles
چکیده انگلیسی
The electronic structure of plasmid DNA both prior to and after its conjugation with Hg nanoparticles (NP) has been investigated here. The DNA molecules undergo severe perturbation on their interaction with Hg-NP. The circular plasmid DNA becomes predominantly linearised on interaction with 10 mM Hg salt solution. These perturbations are also reflected in the electronic structure of C1s and O1s suggesting severe modifications in the exocyclic groups, of the nucleic acid bases, participating in the hydrogen bondings. The results reflect the rupturing of the purine-pyrimidine bonds after interaction with the NP. The study also suggests selective and specific interactions of DNA bases with the Hg nanoparticles leading to the formation of metal-purine-pyrimidine complexes through rupturing of G-C base pairs. Hg-NP exclusively interact with the nitrogen bases of the DNA molecule and do not cause any significant modification to the phosphate backbone of DNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 256, Issue 2, 30 October 2009, Pages 438-442
نویسندگان
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