Mesoporous TiO2 implants for loading high dosage of antibacterial agent

- Mesoporous thin films were fabricated on anodized Ti substrates using a paste comprised of ∼20 nm of pre-synthesized TiO2 nanoparticles.
- High dose of drugs was loaded to the mesoporous thin film due to the film's high surface area.
- A series of antibacterial agents (silver nanoparticles, cephalothin, minocycline, and amoxicillin) were loaded onto the mesoporous thin films and their antibacterial activities were evaluated against five bacterial species.
- Dual-agent loaded thin film showed antibacterial activities against all five tested bacterial species.