کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5359339 | 1388245 | 2011 | 6 صفحه PDF | دانلود رایگان |
In this work, the effects of grafted functional groups and surface wettability on the adhesion of leukocyte and platelet were investigated by the method of blood filtration. The filter materials, poly(butylene terephthalate) nonwoven fabrics bearing different functional groups including hydroxyl (OH), carboxyl (COOH), sulfonic acid group (SO3H) and zwitterionic sulfobetaine group (âN((CH3)2)(CH2)3SO3â) with controllable wettability were prepared by UV radiation grafting vinyl monomers with these functional groups. Our results emphasized that both surface functional groups and surface wettability had significant effects on the adhesion of leukocyte and platelet. In the case of filter materials with the same wettability, leukocytes adhering to filter materials decreased in the order: the surface bearing OH only > the surface bearing both OH and COOH > the surface bearing sulfobetaine group > the surface bearing SO3H, while platelets adhering to filter materials decreased as the following order: the surface bearing SO3H > the surface bearing both OH and COOH > the surface bearing OH only > the surface bearing sulfobetaine group. As the wettability of filter materials increased, both leukocyte and platelet adhesion to filter materials declined, except that leukocyte adhesion to the surface bearing OH only remained unchanged.
Research highlightsⶠSurface functional groups and wettability had obvious impact on blood cell adhesion. ⶠThe surface bearing SO3H had highest platelet adhesion. ⶠThe surface bearing sulfobetaine had lowest platelet adhesion. ⶠThe adhesion of leukocyte to the surface bearing OH only was highest and unchanged. ⶠThe platelet and leukocyte adhesion reduced as the surface wettability increased.
Journal: Applied Surface Science - Volume 257, Issue 7, 15 January 2011, Pages 2978-2983