Ionically crosslinked alginate-carboxymethyl cellulose beads for the delivery of protein therapeutics

► We prepared Fe3+ crosslinked alginate-carboxymethyl cellulose (AC) beads. ► Different surface and inner morphology of AC beads were observed on volume of CMC. ► AC beads showed minimum swelling degree in acidic condition. ► Protein release from AC beads was to control in gastrointestinal condition.