Investigation of biodistribution behavior of platinum particles in mice: Correlation between inductively coupled plasma-atomic emission spectroscopy and X-ray scanning analytical microscopy

► We investigated the biodistribution of platinum microparticles in mice. ► The biodistribution behavior was observed using inductively coupled plasma-atomic emission spectroscopy (ICP) and scanning X-ray analytical microscopy (XSAM). ► The administered particles quickly reached in spleen, liver and lung with constant ration. ► We also estimated the correlation ship between XSAM and ICP measurement. ► The relative ratio of XSAM intensity showed highly correlation with the relative ratio of Pt concentration in organs.