Solid surface dependent layering of self-arranged structures with fibril-like assemblies of alpha-synuclein

► Self-arranged layers of alpha-synuclein based fibrils on the solid surfaces. ► Re-arrangement of β-sheet amyloid fibrils depending on the surface origin. ► Specific transformation of the proteins and the fibrils on the CaF2 and KBr surfaces. ► The surface-protein electrostatic interaction defines the transformation mechanism.