In vitro biocompatibility study of electrospun copolymer ethylene carbonate-ɛ-caprolactone and vascular endothelial growth factor blended nanofibrous scaffolds

► In this study, we synthesized a biodegradable polymer (poly(ethylene carbonate-ɛ-caprolactone) (poly(EC-CL)), and co-electrospun with vascular endothelial growth factor (VEGF) to construct a drug-released nano-scaffolds. ► Our results show that VEGF/poly(EC-CL) blended scaffolds provided good support for endothelial cell growth over the percentages 10 ng/g (VEGF/poly(EC-CL)). ► Our work shows that poly(EC-CL) co-electrospun with VEGF has a great potential for vascular engineering application in the future.