Synthesis of water-soluble FeOOH nanospindles and their performance for magnetic resonance imaging

Water soluble FeOOH nanospindles with small size were synthesized by a simple hydrolysis method of inorganic salts and water bath treatment with different incubation time. The morphology, microstructure, magnetic resonance imaging (MRI) performance and cytotoxicity of the as-prepared FeOOH nanospindles were investigated, respectively. The results showed that the longitudinal length of FeOOH nanospindles was about 40-50 nm, and the incubation time had important effect for the morphology and production rate of FeOOH nanospindles. MRI test showed that the longitudinal and transverse relaxivities (r1 and r2 values) of FeOOH nanospindles were about 3.06 mM−1 s−1 and 5.06 mM−1 s−1, respectively. Furthermore, the experimental results of the Prussian Blue staining showed the clusters of FeOOH nanospindles in the cytoplasm of the labeled cells, and the cytotoxicity characterization indicated that FeOOH nanospindles have low cytotoxicity. Therefore, the as-prepared FeOOH nanospindles will have potential applications as T1- and T2-weighted MRI contrast agents.

► A simple and green method was developed for the synthesis of FeOOH nanospindles. Due to the absence of additional organic reaction agents, the as-prepared FeOOH nanospindles would benefit for the applications in biomedicine. ► A simple and green method was developed for the synthesis of FeOOH nanospindles. Due to the absence of additional organic reaction agents, the as-prepared FeOOH nanospindles would benefit for the applications in biomedicine. ► The as-prepared FeOOH nanospindles showed T1- and T2-weighted magnetic resonance imaging (MRI) performance, and will have potential as MRI contrast agents.